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Acalabrutinib – Overview 💊

Chemical Name: Acalabrutinib
CAS Number: 802518-01-6
Molecular Formula: C₂₆H₂₃N₅O₂

Description:
Acalabrutinib is a selective Bruton's tyrosine kinase (BTK) inhibitor used primarily in the treatment of B-cell malignancies, such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). By inhibiting BTK, Acalabrutinib blocks B-cell receptor signaling, which reduces the proliferation and survival of malignant B-cells.

Appearance:

White to off-white crystalline powder

Solubility:

Practically insoluble in water

Soluble in organic solvents like DMSO and ethanol

Pharmacological Use:

Treatment of B-cell cancers

Often used in patients who are intolerant to other BTK inhibitors

Mechanism of Action:

Irreversibly binds to Bruton's tyrosine kinase (BTK)

Blocks downstream signaling pathways, reducing B-cell proliferation and survival

Dosage Forms:

Oral capsules (commonly 100 mg)

Side Effects (common):

Headache, diarrhea, fatigue

Bruising or bleeding, infections

Rare: cardiac arrhythmias, severe neutropenia