Shanghai Foresight Technology Co., Ltd.

Fraxin A, also known as aescin, is a 6-glucosinolate compound of fraxin B (aescinolone). It is a coumarin-derived natural product, primarily derived from the bark and seeds of plants such as the Oleaceae family's ash (Fraxinus chinensis) and European horse chestnut. Its properties are closely related to fraxin B, and it often coexists with fraxin B in medicinal materials. Main characteristics and pharmacological effects: 1. Chemical properties: As a glycoside compound, its water solubility is generally superior to its aglycone (fraxin B), and it releases fraxin B after metabolism in vivo to exert its effects. 2. Anti-inflammatory and antioxidant effects: It exerts anti-inflammatory and antioxidant effects by inhibiting inflammatory mediators and scavenging free radicals. 3. Antibacterial effects: It has inhibitory effects on certain bacteria and fungi. 4. Improvement of microcirculation and vascular protection: It is believed to enhance venous tone and reduce vascular permeability, and is often used to improve chronic venous insufficiency and microcirculatory disorders. 5. Other effects: Including potential diuretic, anti-edema, and mild analgesic effects. Application Areas: • Pharmaceuticals: In traditional European medicine, it is commonly used to prepare formulations that improve symptoms of varicose veins, leg swelling, and hemorrhoids. • Research Tools: In biochemical research, it is commonly used as a substrate for the detection of β-glucosidase. • Daily Chemicals: Used in small quantities in skincare products that claim to improve capillary function.