GUIZHOU MAIOYAO BIOTECH CO.,LTD

CAS NO:27200-12-0<br />
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Latin Name:Dihydromyricetin/ampelopsin,DH M<br />
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Plant Origin:Tender branches and leaves of big leaf snake grape in grape family plant（Commonly known as rattan tea）.<br />
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Alias:Ampelopsin<br />
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Chemical Name:（2 r, 3 r) - 3, 5, 7 - three hydroxy - 2 - (3 3-5 - three hydroxy phenyl) benzene and dihydro pyran - 4 – ketone<br />
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Molecular Formula:C15H12O8，（320.25）<br />
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Appearance:Yellow powder<br />
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Main Ingredients:Dihydromyricetin 98%<br />
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Physical Property:This product is a white needle crystal (ethanol),easily solve in hot water, hot ethanol and acetone, soluble in ethanol and methanol, very slightly soluble in ethyl acetate can not solve in chloroform, petroleum ether. Microherb research shows that dihydromyricetin has a good thermostability, But with the rise of temperature greater than 100 ℃dihydromyricetin will occur irreversible oxidation reaction. It is stable in neutral and partial acid conditions.<br />
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Efficacy:Dihydromyricetin is an extract from plant rattan tea  belongs to vitis, it is a kind of flavonoids ,the main active ingredient, exsits in Ampelopsis grossedentata, which can scavenging free radicals, antioxidant, antithrombotic, antitumor, anti-inflammatory and many other kinds of peculiar efficacy. Dihydromyricetin is a special kind of flavonoid compounds. It has special efficacy on the time of termination alcohol poisoning, prevention of alcohol liver, fatty liver, inhibiting liver cell degradation, reduce the incidence of hepatocellular carcinoma (HCC), and blood pressure, inhibit platelet aggregation in vitro and in vivo thrombus formation, reduce blood fat and blood sugar levels and raise SOD activity and to protect liver etc.<br />
（1）Antibacterial Action：Pharmacological experiments show that，dihydromyricetin has a bacteriostatic action to hay bacillus, salmonella, staphylococcus aureus, escherichia coli, gas bacillus, beer yeast, sticky red yeast, mould, aspergillus Niger and aspergillus flavus, wool mildew and rhizopus, especially for gram positive and gram negative bacteria aureus and bacillus has obvious effect  <br />
（2）Regulation effect to blood sugar, blood lipid：pharmacology experiment of Lavage in mice shows can significantly inhibited the increase of blood sugar induced by four oxygen pyrimidine, epinephrine, streptozotocin, the increase serum insulin levels, significantly reduce of lymphocytes infiltration, Inflammatory reaction, significantly increased Islet number in pancreatic tissue. Dihydromyricetin also can low the Hyperglycemia rat serum, triacylglycerol, induced by streptozotocin. But it has no obvious effect to the content of serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL2C)<br />
（3）Function of liver protect：Dihydromyricet in can protect the liver cells of in vitro cultured rat which has carbon tetrachloride toxic damage and mice liver injury induced by D2galactosamine and lipopolysaccharide. Besides, it can improve the increase of serum lactate dehydrogenase activity which is caused by hepatocellular injury ,inhibite the formation of collagen fibers of liver cirrhosis M cells so that to protect liver, greatly reduce the liver damage caused by alcohol and make liver recover soon. Microherb research shows that dihydromyricetin can protect live, accelerated decomposition of ethanol metabolic product acetaldehydeand turn it into non-toxic substances so that can reduce the damage to the liver cell. It works quickly and last long. So it indeed a good matter to protect liver and dispel the effects of alcohol.<br />
（4）Antioxygenation： dihydromyricetin98% can restrain the produce of malondialdehyde in rat myocardial,liver and brain homogenate, and this kind of function will strengthen as the increase of the concentration of dihydromyricetin. dihydromyricetin99% has a good clearance to diphenyl trinitrobenzene hydrazine (DPPH) free radicals in test system. It can obviously inhibit the generation of MDA in oil, With two hydrogen arbutus element purity (60% ~ 90%) increase antioxidant effect will be enhanced To animal oil and vegetable oil it all has a strong antioxidant effect.<br />
（5）Anti-tumor Effect：In recent years, anti-tumor pharmacodynamics study found that one of the active constituents, snake grape grain small molecule compounds has a strong anti-cancer effect In vitro antitumor action research found that the compound can inhibit tumor vascular growth, adjust the enhancement of cell immune function and effects to enhance the tumor treatment effect and improve the patient's life, in leukemia and nasopharyngeal carcinoma and tumor model test study shows it has an obvious inhibitory tumor effect.<br />
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Application:Show tooth snake grape also called rattan tea is the traditional folk medicine. It has been widely used in the treatment of skin disease, bouton swollen and osteomyelitis, acute lymphatic infection such as infectious diseases. Dihydromyricetin has widely used in the treatment of respiratory tract infection, alcohol poisoning of traditional Chinese medicine preparation such as tablet, capsule, granule. Its research has set up a file in the preparation of drug resistance of leukemia and nasopharyngeal carcinoma applications made invention patent licensing As a kind of new drug it has been prepared to enter the stage of clinical trials. The development of Chinese herbal medicine new medicine snake grape grain injection is expected to provide a new medicine to the large number of leukemia, nasopharyngeal carcinoma patients. Microherb completed the rattan tea extract (show tooth snake grape flavonoid) and dihydromyricetin extraction and its purification technolog, and also complete the related poison rational experiment and efficacy research besides base on its function and by adding other component it develop instant tea,show tooth snake grape flavonoid lozenge, dihydromyricetin capsule used for dispelling the effects of alcohol and protect liver and other health-care food